Inhibitors of bcrp
WebbInhibitors of the breast cancer resistance protein (BCRP/ABCG2) multidrug transporter are of interest as chemosensitizers for clinical drug resistance, for …
Inhibitors of bcrp
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Webb1 jan. 2006 · Development of P-glycoprotein and BCRP inhibitors First-generation inhibitors of P-glycoprotein were drugs (e.g. verapamil and cyclosporin A) that were … Webb21 aug. 2015 · Inhibitors of the breast cancer resistance protein (BCRP/ABCG2) multidrug transporter are of interest as chemosensitizers for clinical drug resistance, for improving the pharmacokinetics of ...
WebbInhibitors of the P-gp drug efflux pump (also known as P-gp multidrug resistance transporter) listed above may increase serum concentrations of drugs that are substrates of P-gp, whereas inducers of P-gp drug efflux may decrease serum concentrations of substrates of P-gp. WebbIdentifiers Aliases ABCG2, ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group), ABC15, ABCP, BCRP, BCRP1, BMDP, CD338, CDw338, EST157481, GOUT1, MRX, MXR, MXR1, UAQTL1, MXR-1, ATP binding cassette subfamily G member 2 (Junior blood group) External IDs OMIM: 603756MGI: 1347061HomoloGene: …
Webb23 okt. 2003 · Experiments with BCRP-transfected cells also demonstrated low-level resistance to the planar aromatic topoisomerase I inhibitors topotecan (Rabindran et al., 2000) and irinotecan, as well as to SN ... Webb10 maj 2016 · Patients should be tested for hepatitis B virus before starting treatment with BCR-ABL tyrosine kinase inhibitors.
WebbZamicastat (BIA 5-1058) is a dopamine β-hydroxylase (DBH) inhibitor and can cross the blood-brain barrier (BBB) to cause central as well as peripheral effects. Zamicastat is …
Webb5 mars 2024 · The detailed descriptions of the final dataset containing 1098 BCRP inhibitors and 1701 BCRP non-inhibitors. Table S2. The searching space of the Bayesian optimization and the optimal hyper-parameters determined by the Bayesian optimization for all the studied models; Table S3. igh infotec gmbhWebb3 dec. 2024 · Since rimegepant is a substrate of P-gp and BCRP efflux transporters, coadministration of this drug with inhibitors of P-gp or BCRP may significantly increase its exposure [69,70,71,72,73,78,80]. In in vitro studies, ... ighil nacerWebb3 sep. 2010 · A new class of specific breast cancer resistance protein (BCRP) inhibitors was identified, showing no inhibition of the ATP binding cassette (ABC) … ighir tinghirWebb2 juli 2014 · Testing for substrates and inhibitors of BCRP using VT assays is of particular importance as BCRP is known to have many low passive permeable substrates and inhibitors (Poirier et al., 2014),... igh in wordsWebbAn androgen receptor inhibitor used to treat non-metastatic castration-resistant and metastatic castration-sensitive prostate cancer. Investigated for use/treatment in multiple myeloma and solid tumors. A hormone used for a variety of functions, including contraception, control of abnormal uterine bleeding, maintenance of pregnancy, and ... ighisiWebb31 dec. 2013 · Due to the binding competition, some substrates for BCRP/ABCG2 have also been recognized as inhibitors of BCRP/ABCG2 when other BCRP/ABCG2 substrates were used simultaneously. Therefore, co-treatment with other anti-cancer drugs, which were also defined as BCRP/ABCG2 substrate, may be an alternative way to … is thc legal in madison wiWebbInhibition of intestinal BCRP has shown to be responsible for clinical drug-drug interactions. For example, the BCRP inhibitor fostamatinib inhibits the transport of the … igh in kpmg