2024 Glutamate antagonists limit tumor growth

Glutamate antagonists limit tumor growth

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August undefined, 2024

WebMay 22, 2001 · Glutamate antagonists limit tumor growth Proc Natl Acad Sci U S A. 2001 May 22;98(11):6372-7. doi: 10.1073/pnas.091113598. Epub 2001 May 1. Authors … WebJun 1, 2001 · Moreover, investigations showed that glutamate receptor antagonists, including the potent mGluR3 antagonist LY341495, limit tumor growth [66, 69]. While …

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Webmigration of tumor cells. To study the effect of glutamate on tumor growth, various Ab tumor cell lines were exposed to NMDA and AMPA antagonists isox and glutamate, and the proliferation, morphology, and migration mic of tumor cells was evaluated. It was found that glutamate mel antagonists inhibit, whereas glutamate stimulates proliferation ben WebAntagonists of the NMDA receptor act either by competitive antagonism at the glutamate-binding site or by noncompetitive antagonism at the glycine, phencyclidine (PCP)-, and … miley love

Glutamate antagonists limit tumor growth. - Europe PMC

WebJan 1, 2014 · As earlier discussed, increased levels of glutamate in the extracellular spaces can lead to neurodegeneration by promoting glutamate excitotoxicity. This represents an alternative mechanism for the promotion and expansion of … WebOct 12, 2005 · The antiproliferative effect of glutamate antagonists was Ca 2+ dependent and resulted from decreased cell division and increased cell death. Furthermore, glutamate antagonists decreased motility and invasive growth of tumor cells. These findings point to the anticancer potential of glutamate antagonists [ 16, 17 ]. WebNov 1, 2002 · Furthermore, glutamate antagonists have been shown to limit tumor growth, migration, and invasiveness in human tumors, including breast, colon, lung, … new yorker thanksgiving cartoon

Glutamatergic synaptic input to glioma cells drives brain ... - Nature

Glutamate antagonists limit tumor growth - ScienceDirect

WebJul 29, 2015 · Glutamate antagonists, for example, inhibit cell proliferation [ 8 – 10] and induce cell cycle arrest [ 11] and cell death [ 12] in some tumor entities. MK 801 was used for this purpose in many preclinical studies [ 13 ], but the psychotropic effects of this glutamate antagonist significantly restrict its clinical application. WebJun 1, 2007 · Several groups reported that glutamate receptor antagonists limit tumor growth (Arcella et al. 2005; Nicoletti et al. 2007; Rzeski et al. 2001). Recent data show that blocking expression of ... miley liam weddingWebmigration of tumor cells. To study the effect of glutamate on tumor growth, various Ab tumor cell lines were exposed to NMDA and AMPA antagonists isox and glutamate, … miley lightning

"WebJul 18, 2014 · Previous studies demonstrated that inhibition of glioma glutamate release or blockade of glutamate receptors could limit tumor growth [9], [10]. However, ammonia is produced when glutamine is deamidated to glutamate by glutaminase, which could induce astrocyte swelling and dysfunction of glutamate uptake via excessive oxidative stress … " - Glutamate antagonists limit tumor growth

Glutamate antagonists limit tumor growth

Frontiers Glutamate Signaling in Healthy and Diseased Bone

WebIn this respect, therapeutic inhibition of system x c – in the cancer cells may relieve bone pain symptoms by reducing their glutamate secretion while simultaneously preventing tumor growth, reducing bone disruption, and sensitizing the tumor to radiation or chemotherapeutic agents. Rheumatoid Arthritis WebMar 28, 2013 · ), another ionotropic glutamate receptor; in contrast, there is little evidence implicating glutamate signaling via NMDAR in cancer phenotypes. Motivated by these various considerations, we sought to …

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WebMar 13, 2024 · Glutamatergic signaling significantly promotes proliferation, migration, and invasion in glioblastoma (GBM). Riluzole, a metabotropic glutamate receptor 1 inhibitor, reportedly suppresses GBM growth. However, the effects of combining riluzole with the primary GBM chemotherapeutic agent, temozolomide (TMZ), are unknown. WebAug 14, 2012 · Glutamate is a major excitatory neurotransmitter of the central nervous system (CNS) that potentiates processes such as neuronal precursor-cell proliferation, …

WebJul 7, 2001 · MEDICAL SCIENCES. For the article “Glutamate antagonists limit tumor growth” by Wojciech Rzeski, Lechoslaw Turski, and Chrysanthy Ikonomidou, which appeared in number 11, May 22, 2001, of Proc. Natl. Acad. Sci.USA (98, 6372–6377; First Published May 1, 2001; 10.1073/pnas.091113598), the authors note that Dr. Turski's … WebMay 1, 2001 · Search worldwide, life-sciences literature Search. Advanced Search Coronavirus articles and preprints Search examples: "breast cancer""breast cancer"

WebSep 1, 2001 · It follows that if glutamate release by tumors is directly responsible for their growth, then blocking 'downstream' glutamate receptors should slow growth. … WebMay 1, 2001 · Europe PMC is an archive of life sciences journal literature.

WebOct 15, 2002 · Glutamate antagonists and tumor growth. In a series of recently conducted experiments [22], we were able to demonstrate that glutamate antagonists …

WebMay 22, 2001 · The stimulatory effect of glutamate on tumor growth under serum deprivation suggests that glutamate itself can elicit trophic effect on tumor cells. Ca 2+ … miley ludwig randolph southernWebOct 15, 2002 · Glutamate antagonists produce morphological alterations in tumor cells, which consist of reduced membrane ruffling and pseudopodial protrusions, and decrease … miley malloy authorWebOct 25, 2005 · Glutamate antagonists limit the growth of human cancers in vitro. The mechanism of anticancer action of NMDA antagonists is not known, however. miley love songsWebNov 1, 2002 · Glutamate antagonists produce morphological alterations in tumor cells, which consist of reduced membrane ruffling and pseudopodial protrusions, and decrease their motility and invasive... miley miley shrimp shackWebOct 15, 2002 · The antiproliferative effect of glutamate antagonists is Ca(2+)-dependent and results from decreased cell division and increased cell death. Glutamate … new yorker television criticWebMay 1, 2001 · The stimulatory effect of glutamate on tumor growth under serum deprivation suggests that glutamate itself can elicit trophic effect on tumor cells. Ca 2+ … miley mac cosmeticsWebThe discovery of anticancer activity of glutamate antagonists provides new challenges for cancer biologists and the pharmaceutical industry. One crucial issue to resolve is … miley mattress reviews