WebAn epistatic ratchet constrains the direction of glucocorticoid receptor evolution. Jamie T. Bridgham, University of Oregon Eric Ortlund, Emory University Joseph W. Thornton, … WebNov 13, 2015 · Epistatic interactions can frustrate and shape evolutionary change. Indeed, phenotypes may fail to evolve when essential mutations are only accessible through positive selection if they are fixed simultaneously. How environmental variability affects such constraints is poorly understood.
High-order epistasis shapes evolutionary trajectories PLOS ...
Web7 Bridgham JT, Ortlund EA, Thornton JW (2009) An epistatic ratchet constrains the direction of glucocorticoid receptor evolution. Nature 461(7263):515–519. 8 Akanuma S, et al. (2013) Experimental evidence for the thermophilicity of ancestral life. Proc Natl Acad Sci USA 110(27):11067–11072. Epistasis is a phenomenon in genetics in which the effect of a gene mutation is dependent on the presence or absence of mutations in one or more other genes, respectively termed modifier genes. In other words, the effect of the mutation is dependent on the genetic background in which it appears. … See more Understanding of epistasis has changed considerably through the history of genetics and so too has the use of the term. The term was first used by William Bateson and his collaborators Florence Durham See more Additivity This can be the case when multiple genes act in parallel to achieve the same effect. For example, when an organism is in need of See more Regression analysis Quantitative genetics focuses on genetic variance due to genetic interactions. Any two locus interactions at a particular gene frequency can be decomposed into eight independent genetic effects using a weighted regression. … See more Terminology about epistasis can vary between scientific fields. Geneticists often refer to wild type and mutant alleles where the mutation is … See more Fitness landscapes and evolvability In evolutionary genetics, the sign of epistasis is usually more significant than the magnitude of epistasis. This is because magnitude … See more • Co-adaptation • Epistasis and functional genomics • Mutation • Synthetic viability See more • INTERSNP - a software for genome-wide interaction analysis (GWIA) of case-control and case-only SNP data, including analysis of … See more baker number 9
Generated an epistatic ratchet, which made the …
WebJan 25, 2016 · A landmark study of reverse evolution in the vertebrate glucocorticoid receptor identified a combination of five mutations, labelled an ‘epistatic ratchet’, that … WebJun 25, 2012 · Epistatic capture is the stabilization of a TFBS that is ancestral but variable in outgroup lineages, and is fixed in the ingroup because of epistatic interactions with derived TFBSs. Finally, we note that evolution of human promoter activity coincides with the emergence of a unique reproductive character in apes, highly invasive placentation. arbaeen karbala live