Cyclic pifithrin-α
WebJul 17, 2024 · Zuco, V.; Zunino, F. Cyclic pifithrin-α sensitizes wild type p53 tumor cells to antimicrotubule agent-induced apoptosis. Neoplasia 2008 , 6 , 587–596. [ Google Scholar ] [ CrossRef ] WebPifithrin-α ≥95% (HPLC), powder Synonym (s): 2- (2-Imino-4,5,6,7-tetrahydrobenzothiazol-3-yl)-1-p-tolylethanone hydrobromide, PFT-α Linear Formula: C16H18N2OS·HBr CAS Number: 63208-82-2 Molecular …
Cyclic pifithrin-α
Did you know?
Web【编号】：PR3965 【产品名称】：三叶海棠素对照品 【规格】：10mg 【用途】： 三叶海棠素对照品 WebNov 7, 2005 · Likewise, cyclic pifithrin also blocked CCN1-induced apoptosis in HSFs (Fig. 6 C). Thus, CCN1-induced apoptosis requires p53 function, which mediates the activation of Bax. ... cyclic pifithrin-α, and cycloheximide were purchased from Calbiochem. The mitochondrion-selective probe MitoTracker Orange was obtained from Invitrogen. ...
WebPifithrin-α is a reversible inhibitor of p53-mediated apoptosis and p53-dependent gene transcription such as cyclin G, p21/waf1, and mdm2 expression. Pifithrin-α enhances … WebJan 23, 2024 · In contrast, pretreatment with a p53 inhibitor (cyclic pifithrin-α) did not prevent RCX-induced apoptosis, indicating the activation of a p53-independent apoptosis pathway. RCX also presented a...
http://shiji.cnreagent.com/s/sv253508.html WebCyclic Pifithrin-α hydrobromide has been used as p53 inhibitor to study its role in cigarette smoke−induced apoptosis of pulmonary endothelial cells. [ 1] Packaging 5, 10 mg in …
WebJan 23, 2024 · Pifithrin-α (PFT-α) is a small molecule which has been widely used as a specific inhibitor of p53 transcription activity. However, its molecular mechanism of action …
WebPifithrin-α, p-Nitro, Cyclic - CAS 60477-38-5 - Calbiochem A cell-permeable p53 inhibitor that exhibits 10-fold higher potency and 50% longer half-life than Pifithrin-α. - Find MSDS or SDS, a COA, data sheets and more information. c\u0027s englishWebCyclic PFT-α 是 PFT-α 的稳定类似物。 p-nitro-Cyclic PFT-α 是一种可渗透细胞的环状 PFT-α。 在保护暴露于依托泊苷 (ED50 = 30 nM) 的皮质神经元方面，它比 PFT-α 活性高一个数量级。 p-nitro-Cyclic PFT-α 以 p53 依赖性方式起作用，但不会阻断响应依托泊苷处理的 Ser15 … east anglian yarn crawlWebPifithrin-α is a synthetic, water-soluble and stable inhibitor of p53 [1]. Pifithrin-α is firstly found to block the activation of p53-responsive lacZ in ConA cells and reduce activation of endogenous cellular p53-responsive genes. ... A4477 Cyclic Pifithrin-α hydrobromide. A4204 JNJ-26854165 (Serdemetan) A4487 WR 1065. A4203 Tenovin-1 ... east anglian waterfowlWebIn brief, the cells were pretreated for 2 h with 50 μM Z-DEVD-FMK and 10 μM cyclic pifithrin-α and for 1 h with 5 mM NAC, followed by incubation with 14 μM xylopine for 48 h. The cells were then trypsinized and the FITC Annexin V Apoptosis Detection assay was conducted as described above. 2.8. c \u0027sdeathWebPifithrin-α, p-Nitro, Cyclic (PFN-α) is cell-permeable and active-form p53 inhibitor. Pifithrin-α, p-Nitro, Cyclic is one order magnitude more active than Pifithrin-α in protecting cortical neurons exposed to Etoposide (ED 50 =30 nM). Pifithrin-α, p-Nitro, Cyclic behaves as a p53 posttranscriptional activity inhibitor. east anglian waterwaysWebPifithrin-β hydrobromide (PFT β hydrobromide) is a potent p53 inhibitor with an IC50 of 23 μM. For research use only. We do not sell to patients. Pifithrin-β hydrobromide Chemical Structure CAS No. : 511296-88-1 Get it April 11 by noon. Order within 21 hrs 30 mins. or Bulk Inquiry * Please select Quantity before adding items. east anglian water companyWebCyclic PFT-α was a stable analog of PFT-α. p-nitro-Cyclic PFT-α, a cell-permeable form of cyclic PFT-α, was found to be one order of magnitude more active than PFT-α in protecting cortical neurons exposed to etoposide. p-nitro-Cyclic PFT-α acted in a p53-dependently but did not block phosphorylation of p53 on Ser15 in response to etoposide … c\u0027s country diner